High dose infusion of activated protein C (rhAPC) fails to improve neuronal damage and cognitive deficit after global cerebral ischemia in rats.

Melanie Brückner,Irina Lasarzik,Antje Jahn-Eimermacher,Dirk Peetz,Christian Werner,Kristin Engelhard,Serge C Thal

Neuroscience Letters（2013）

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摘要

•The pharmacokinetic profile in rats revealed a short half-life of seven minutes.•Stable rhAPC plasma levels were achieved with 2mg/kg bolus and 6mg/kg/h IV infusion.•5h of rhAPC after cerebral ischemia failed to reduce neuronal cell deaths.

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关键词

Global cerebral ischemia,Activated protein C,Drotrecogin alfa,Inflammation,Coagulation,Neuroprotection

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