Improving influenza virus backbones by including terminal regions of MDCK-adapted strains on hemagglutinin and neuraminidase gene segments.

Raúl C Gomila,Pirada Suphaphiphat,Casey Judge,Terika Spencer,Annette Ferrari,Yingxia Wen,Giuseppe Palladino,Philip R Dormitzer,Peter W Mason

Vaccine（2013）

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摘要

•Chimeric HA and NA gene segments with terminal regions from MDCK-adapted strains were created.•Reassortant viruses created with these chimeric segments produced more HA.•Combining HA and NA chimeric segments proved superior to chimeric HA or NA only.

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关键词

Influenza,Reverse genetics,Hemagglutinin,Chimeras,Vaccine seeds

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