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Functional bias and spatial organization of genes in mutational hot and cold regions in the human genome.

PLOS BIOLOGY, no. 2 (2004): 253-263

Cited: 58|Views27
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Abstract

The neutral mutation rate is known to vary widely along human chromosomes, leading to mutational hot and cold regions. We provide evidence that categories of functionally related genes reside preferentially in mutationally hot or cold regions, the size of which we have measured. Genes in hot regions are biased toward extracellular communi...More

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