[The Effect of Adriamycin to the Trigeminal Ganglion Following Injection into the Rabbits Infraorbital Nerve].

OBJECTIVE:To observe the effect of adriamycin to suborbital nerve and trigeminal ganglion in the rabbits.METHODS:20 microliters adriamycin with different concentrations of 0.5%, 1.0%, 3.0%, 5.0% were injected into the suborbital nerve trunks, respectively. The changes of compound action potential (CAP), autofluorescence and histological feature in suborbital nerve and trigeminal ganglion were observed.RESULTS:With suitable adriamycin concentration, autofluorescence could be observed at 10 hours after injection, and reached highest at 20 hours. CAP amplitudes reduced at 10 h, disappeared after 20 h and could not be stimulated after 6 months. Morphological change began after 15 d and became obvious with time going. The regeneration of neurons was not observed 6 months after injection, while the tissue surrounding the necrotic nerve and ganglion cells were normal morphologically.CONCLUSIONS:Adriamycin can damage axons and corresponding ganglion cells by the way of suicide transport permanently, but the damage was highly selective and self-limited.