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Specificity of regulatory CD4+CD25+ T cells for self-T cell receptor determinants.

JOURNAL OF NEUROSCIENCE RESEARCH, no. 1 (2004): 129-140

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Although the phenotypic and regulatory properties of the CD4(+)CD25(+) T cell lineage (Treg cells) have been well described, the specificities remain largely unknown. We demonstrate here that the CD4(+)CD25(+) Treg population includes the recognition of a broad spectrum of human TCR CDR2 determinants found in the germline V gene repertoir...更多

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