Involvement of the chemokine RANTES (CCL5) in resistance to experimental infection with Leishmania major.

Helton da Costa Santiago,Carolina Ferreira Oliveira, Luciana Santiago,Fernanda Oliveira Ferraz,Daniele da Glória de Souza,Luiz Antônio Rodrigues de-Freitas,Luís Carlos Crocco Afonso,Mauro Martins Teixeira,Ricardo Tostes Gazzinelli,Leda Quercia Vieira

INFECTION AND IMMUNITY（2004）

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摘要

The expression and putative role of chemokines during infection with Leishmania major in mice were investigated. CCL5 expression correlates with resistance, and blockade of CCL5 rendered mice more susceptible to infection. CCL5 is part of the cascade of events leading to efficient parasite control in L. major infection.

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