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Intracellular uptake and inhibition of gene expression by PNAs and PNA-peptide conjugates.

BIOCHEMISTRY, no. 45 (2004): 14340-14347

被引用44|浏览3
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Peptide nucleic acids (PNAs) offer a distinct option for silencing gene expression in mammalian cells. However, the full value of PNAs has not been realized, and the rules governing the recognition of cellular targets by PNAs remain obscure. Here we examine the uptake of PNAs and PNA-peptide conjugates by immortal and primary human cells ...更多

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