Neuronal ablation of p-Akt at Ser473 leads to altered 5-HT1A/2A receptor function.

Christine Saunders,Michael Siuta,Sabrina D Robertson,Adeola R Davis,Jennifer Sauer,Heinrich J G Matthies,Paul J Gresch,David Airey,Craig W Lindsley,John A Schetz,Kevin D Niswender,Jeremy M Veenstra-Vanderweele,Aurelio Galli

Neurochemistry International（2014）

引用 15|浏览14

暂无评分

摘要

•Neuronal insulin regulates central monoamine homeostasis via down-stream kinase Akt.•Neuronal ablation of p-Akt at Ser473 increases cortical 5-HT1A and -2A receptors.•Elimination of p-Akt at Ser473 changes 5-HT receptor subtype signaling and behaviors.•We identified a novel link between Akt dysfunction (diabetes) and mental illness.

查看译文

关键词

5-HT,Akt,DOI,ERK1/2,GSK-3β,KO,8-OH-DPAT,HTR,SERT

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要