SV2A and SV2C contain a unique synaptotagmin-binding site

Molecular and Cellular Neuroscience, pp. 56-64, 2005.

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Abstract:

SV2 (Synaptic Vesicle Protein 2) is expressed in neurons and endocrine cells where it is required for normal calcium-evoked neurosecretion. In mammals, there are three SV2 genes, denoted SV2A, B and C. SV2A interacts with synaptotagmin, the prime candidate for the calcium sensor in exocytosis. Here, we report that all isoforms of native S...More

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