Arsenic induces reactive oxygen species-caused neuronal cell apoptosis through JNK/ERK-mediated mitochondria-dependent and GRP 78/CHOP-regulated pathways.

Tien-Hui Lu,To-Jung Tseng,Chin-Chuan Su,Feng-Cheng Tang,Cheng-Chieh Yen, Yu-Yun Liu,Ching-Yao Yang,Chin-Ching Wu,Kuo-Liang Chen,Dong-Zong Hung,Ya-Wen Chen

Toxicology Letters（2014）

引用 148|浏览10

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摘要

•Inorganic arsenic (iAs) induced oxidative stress leading to neuronal cell apoptosis.•iAs caused JNK/ERK activation-mediated mitochondria-dependent caspase cascades pathway.•iAs was capable of inducing GRP78 and CHOP activations-regulated apoptotic signals.

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关键词

ROS,MAPKs,JNK,ERK,Nrf2,PARP,NAC,ER stress,GRP,CHOP,XBP-1,si-RNA,MMP

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