Early stationary phase culture supernatant accelerates growth of sputum cultures collected after initiation of anti-tuberculosis treatment.

E Kolwijck,S O Friedrich,M N Karinja,J van Ingen, R M Warren,A H Diacon

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases（2013）

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摘要

We investigated the effect of Mycobacterium tuberculosis culture supernatant added to sputum cultures collected during the first 8 weeks of anti-tuberculosis treatment. With ongoing treatment duration, time to culture positivity decreased significantly in supernatant-enriched cultures, possibly due to stimulation of dormant or slowly metabolizing M. tuberculosis cells.

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