Caspase inhibition augments Dichlorvos-induced dopaminergic neuronal cell death by increasing ROS production and PARP1 activation.

•PJ34 prevents Dichlorvos-induced PC12 cell death.•Caspase inhibition transiently protects against Dichlorvos-induced PC12 cell death.•Caspase inhibition augments PC12 cell death by the activation of PARP1.•Combined treatment with caspase and PARP1 inhibitor provides superior protection.