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Nrf2 regulates the expression of the peptide transporter PEPT1 in the human colon carcinoma cell line Caco-2.

Biochimica et Biophysica Acta (BBA) - General Subjects(2014)

Cited 19|Views9
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Abstract
•Pept1 expression is of great interest for drug delivery.•The Pept1 promoter contains 4 ARE sites.•EMSA and ChIP analysis show Nrf2 binding to Pept1-ARE1.•Resveratrol, sulforaphane and MG132 induce PEPT1 expression.
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Key words
ARE,NRF2,NQO1,γGCS,CNC,LAMP1,GS,GPx4,GI-GPx,GSH
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