Amphetamine reward in food restricted mice lacking the melanin-concentrating hormone receptor-1.

Annabelle Geuzaine,Amélie Tyhon,Thierry Grisar,Christian Brabant,Bernard Lakaye,Ezio Tirelli

Behavioural Brain Research（2014）

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摘要

•Food restriction increases the rewarding potency of drugs.•The MCH pathway is well located to influence reward.•CPP induced by amphetamine is not enhanced by food restriction in MCHR1-KO mice.•The MCH signaling might play a role in the effect of food restriction on drug reward.

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关键词

CPP,D1R,D2R,FF,FR,LH,MCH,MCHR1,MCHR1-KO,WT

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