Minocycline inhibits angiogenesis in vitro through the translational suppression of HIF-1α.

•Minocycline inhibits HIF-1α protein expression through suppression of protein translation.•Minocycline exhibits anti-angiogenic property through suppression of HIF-1α expression.•Minocycline inhibits protein translation through the suppression of mTOR signaling and phosphorylation of eIF2α.