Fatty acid epoxyisoprostane E2 stimulates an oxidative stress response in endothelial cells.

Xinmin Yan,Sangderk Lee,B Gabriel Gugiu,Lukasz Koroniak,Michael E Jung,Judith Berliner,Jinluo Cheng,Rongsong Li

Biochemical and Biophysical Research Communications（2014）

引用 16|浏览8

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摘要

•Epoxyisoprostane E2 (EI) induced oxidative stress in endothelial cells.•EI stimulated the expression of oxidative stress response gene OKL38 and HO-1.•EI stimulated oxidative stress response genes via Nrf2 signaling.

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关键词

EI,OxPL,OxPAPC,PEIPC,POVPC,PGPC,PUFA,PLA2,HETE,HODE,HDL,HAEC,ROS,Nox,Nrf2,ARE,HO-1,NAC

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