Platelets store laminins 411/421 and 511/521 in compartments distinct from α‐ or dense granules and secrete these proteins via microvesicles

M. Pook, L. Tamming, K. Padari,T. Tiido, T. Maimets,M. Patarroyo, E. Juronen,V. Jaks,S. Ingerpuu

Journal of Thrombosis and Haemostasis(2014)

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摘要
We demonstrate that laminins 411/421 and 511/521 are present in compartments of platelets that do not express α-granule, dense granule, or lysosome marker proteins. Moreover, laminins secreted by activated platelets are mostly found in microvesicles shed from the plasma membrane, while their presence in simultaneously released exosomes is minimum.
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关键词
blood platelets,cell‐derived microparticles,exosomes,laminin,platelet activation
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