A catalytic-independent role for the LUBAC in NF-κB activation upon antigen receptor engagement and in lymphoma cells
Blood(2014)
摘要
Key Points LUBAC elements HOIP and SHARPIN participate in T-cell receptor-mediated NF-κB activation independently of HOIP catalytic activity. LUBAC silencing compromises constitutive NF-κB activation and cell survival in ABC DLBCL lines.
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关键词
lubac,antigen receptor engagement,lymphoma,catalytic-independent
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