Concomitant PIK3CA amplification and RASSF1A or PAX6 hypermethylation predict worse survival in gastric cancer.

Yang Qi,Shao Yuan,Shi Jing,Qu Yiping,Wu Kexia,Dang Siwen,Shi Bingyin,Hou Peng

Clinical Biochemistry（2014）

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摘要

•PIK3CA amplification was specifically found in gastric cancers.•RASSF1A and PAX6 genes were frequently methylated in gastric cancers.•PIK3CA amplification with RASSF1A or PAX6 methylation undermines clinical outcomes.

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关键词

Q-MSP,PIK3CA,RASSF1A,PAX6,SDS,H&E,FISH

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