Unique BHLHB3 overexpression in pediatric acute myeloid leukemia with t(6;11)(q27;q23)

E A Coenen,C M Zwaan, J Stary,A Baruchel,V de Haas,R W Stam, D Reinhardt,G J L Kaspers, S T C J M Arentsen-Peters, C Meyer,R Marschalek,L L Nigro,M Dworzak,R Pieters,M M van den Heuvel-Eibrink

LEUKEMIA（2014）

引用 4|浏览4

暂无评分

摘要

Within pediatric MLL-rearranged acute myeloid leukemia (AML), the translocation partners have been shown to be clinically highly relevant.1 The most striking example is the t(6;11)(q27;q23) subtype, which has an event-free survival of only 11% and estimated overall survival of only 22%.1 This poor outcome is determined by a high induction-failure rate (26%), as well as a high-relapse rate (57%).1

查看译文

关键词

LEU, oncology, haematology, immunology, leukemia, stem cells, oncogenes, growth factors, apoptosis, therapy, fusion genes, lymphoma, hemopoiesis

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要