GATA-4 induces changes in electrophysiological properties of rat mesenchymal stem cells.

Hong-Xia Li,Ya-Feng Zhou,Bin Jiang,Xin Zhao,Ting-Bo Jiang,Xun Li,Xiang-Jun Yang,Wen-Ping Jiang

Biochimica et Biophysica Acta (BBA) - General Subjects（2014）

引用 6|浏览49

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摘要

•GATA-4 transduced MSC exhibit increased INa.TTX, ICa.L, Ito, IKDR and IK1 currents.•GATA-4 transduced MSC display cardiomyocyte-like morphologies.•VEGF and IGF-1 secretion is increased in GATA-4 transduced MSC.•VEGF and IGF-1 secretion regulates ion channel expression in GATA-4 transduced MSC.

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关键词

CM,MSC,MSCNull,MSCGATA-4,IK1,IKDR,Ito,INa.TTX,ICa.L,CCHL2a,GAPDH,Kir,Kv

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