Up-regulation of microRNA-190b plays a role for decreased IGF-1 that induces insulin resistance in human hepatocellular carcinoma

PloS one, Volume 9, Issue 2, 2014, Pages e89446-e89446.

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case control studiesgene expression profilingmicrornasreal time polymerase chain reactionapoptosisMore(2+)

Abstract:

Insulin-like growth factor, (IGF)-1, is produced mainly by the liver and plays important roles in promoting growth and regulating metabolism. Previous study reported that development of hepatocellular carcinoma (HCC) was accompanied by a significant reduction in serum IGF-1 levels. Here, we hypothesized that dysregulation of microRNAs (mi...More

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