Epigenetic-related gene expression profile in medullary thyroid cancer revealed the overexpression of the histone methyltransferases EZH2 and SMYD3 in aggressive tumours.

Marialuisa Sponziello,Cosimo Durante,Amelie Boichard,Mariavittoria Dima,Cinzia Puppin,Antonella Verrienti,Giulia Tamburrano,Giorgio Di Rocco,Adriano Redler,Ludovic Lacroix,Jean-Michel Bidart,Martin Schlumberger,Giuseppe Damante,Diego Russo,Sebastiano Filetti

Molecular and Cellular Endocrinology（2014）

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摘要

•Epigenetic machinery may be involved in the progression of MTC.•A common gene expression pattern of the more aggressive tumours was revealed.•EZH2 and SMYD3 are associated with occurrence of distant metastases in MTCs.

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关键词

MTC,TLDA,RET

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