Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation.

Johan D Oslob,Russell J Johnson,Haiying Cai,Shirley Q Feng,Lily Hu,Yuko Kosaka,Julie Lai,Mohanram Sivaraja,Samnang Tep,Hanbiao Yang,Cristiana A Zaharia,Marc J Evanchik,Robert S McDowell

ACS medicinal chemistry letters（2013）

引用 36|浏览11

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摘要

Potent imidazopyridine-based inhibitors of fatty acid synthase (FASN) are described. The compounds are shown to have antiviral (HCV replicon) activities that track with their biochemical activities. The most potent analogue (compound 19) also inhibits rat FASN and inhibits de novo palmitate synthesis in vitro (cell-based) as well as in vivo.

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关键词

fasn,hcv,antiviral,in vivo,inhibitor,reversible,structure−activity relationship,target modulation,bioinformatics,biomedical research

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