Regio- and stereoselective access to novel ring-condensed steroidal isoxazolines.

•Isoxazoline hetero rings were introduced into the sterane nucleus.•Intermolecular alkene–nitrile oxide cycloadditions were carried out.•The reactivities of the enone moiety of rings A and D were compared.•Behaviour of the synthetized compounds under deacetylation was studied.•The structures of all novel compounds were confirmed by NMR measurements.