Chronic low-level domoic acid exposure alters gene transcription and impairs mitochondrial function in the CNS.

Emma M Hiolski,Preston S Kendrick,Elizabeth R Frame,Mark S Myers,Theo K Bammler,Richard P Beyer,Federico M Farin,Hui-Wen Wilkerson,Donald R Smith,David J Marcinek,Kathi A Lefebvre

Aquatic Toxicology（2014）

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摘要

•Low-level seafood toxin exposure alters gene transcription in the CNS.•Transcriptional responses to low-level exposure are highly dynamic over time.•Transcriptome alterations occur in genes related to nervous system function.•Low-level seafood toxin exposure impairs mitochondrial function.•Low-level seafood toxin exposure induces compensatory mitochondrial biogenesis.

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关键词

Domoic acid,Chronic toxin exposure,Microarray,Subclinical effects

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