The marine toxin palytoxin induces necrotic death in HaCaT cells through a rapid mitochondrial damage.

Marco Pelin,Silvio Sosa,Sabrina Pacor,Aurelia Tubaro,Chiara Florio

Toxicology Letters（2014）

引用 22|浏览4

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摘要

•PLTX induces an early and irreversible necrotic cell death.•Apoptosis occurrence was excluded.•Necrosis is related to an early mitochondrial depolarization already after 5min.•Mitochondrial damage is strictly dependent on ionic imbalance.

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关键词

BNIP3,LDH,DAPI,DIL,DMA,ENaC,MFI,MTT,MPTPs,PI,PBS,PLTX,PFA,NHE,ROS,TTBS

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