A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site

Mary Ann Hardwicke,Alan R Rendina,Shawn P Williams,Michael L Moore,Liping Wang,Julie A Krueger, Ramona N Plant,Rachel D Totoritis,Guofeng Zhang,Jacques Briand, William A Burkhart,Kristin K Brown,Cynthia A Parrish

Nature chemical biology（2014）

引用 77|浏览23

暂无评分

摘要

small-molecule compound, GSK2194069, specifically inhibits the β-ketoacyl reductase (KR) activity of the human fatty acid synthase. A co-crystal structure of the KR domain with the inhibitor confirms this interaction.

查看译文

关键词

nature chemical biology, science

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要