Radiation promotes malignant progression of glioma cells through HIF-1alpha stabilization.

Young-Heon Kim,Ki-Chun Yoo,Yan-Hong Cui,Nizam Uddin,Eun-Jung Lim,Min-Jung Kim,Seon-Young Nam,In-Gyu Kim,Yongjoon Suh,Su-Jae Lee

Cancer Letters（2014）

引用 59|浏览3

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摘要

•Irradiation promotes invasiveness and angiogenesis of glioma cells through HIF1α.•Irradiation increases the stability of HIF1α even in normoxia through p38 MAPK.•Radiation-activated p38 increases HIF1α protein by destabilization of PHD-2 and pVHL.

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关键词

Hypoxia inducible factor 1 alpha,Angiogenesis,Infiltration of glioma cells,Ionizing radiation,p38 MAPK

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