AGAP, a new recombinant neurotoxic polypeptide, targets the voltage-gated calcium channels in rat small diameter DRG neurons.

Xifang Liu,Chunli Li,Jianzhao Chen,Jingnan Du,Jinghai Zhang,Guixia Li,Xiaoquan Jin,Chunfu Wu

Biochemical and Biophysical Research Communications（2014）

引用 19|浏览30

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摘要

•AGAP reduced the calcium currents in a concentration-, voltage-dependent manner.•AGAP more strongly inhibited HVA calcium channels than LVA calcium channels.•AGAP more strongly inhibited N-type channel than other HVA channel subtypes.

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关键词

Calcium channel,Scorpion toxin,AGAP,Whole-cell patch clamp,Dynamic function

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