A method to quantitate the neutralizing capacity of anti-therapeutic protein antibodies in serum and their correlation to clinical impact.

•Describes a method to quantitate clinically relevant neutralizing anti-drug antibodies.•Makes easier comparison and correlation of NAbs within and/or across studies.•Method can be used across different platforms routinely used for NAb detection.•Useful across multiple therapeutic targets and analytical methods for standardization.•Useful in characterization of NAb positive controls for consistent and high quality reagents.