Tanshinone IIA attenuates hypoxic pulmonary hypertension via modulating KV currents.

•We investigated whether KV channels were responsible for the protective effect of TIIA on chronic hypoxic pulmonary hypertension.•TIIA markedly recovered the down-regulation of IKV currents in pulmonary artery smooth muscle cells (PASMCs) induced by acute hypoxia.•TIIA significantly restrained chronic intermittent hypoxia or sustained hypoxia-induced pulmonary artery wall remodeling, accompanied with modulating the expressions of KV2.1 and KV1.5, and reversing the down-regulation of IKV currents.•TIIA is thus an attractive potential therapy for CH-PH.