Amyloid precursor protein knockout diminishes synaptic vesicle proteins at the presynaptic active zone in mouse brain

CURRENT ALZHEIMER RESEARCH, pp. 971-980, 2014.

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Abstract:

The amyloid precursor protein (APP) has previously been allocated to an organellar pool residing in the Golgi apparatus and in endosomal compartments, and in its mature form to a presynaptic active zone-localized pool. By analyzing homozygous APP knockout mice we evaluated the impact of APP on synaptic vesicle protein abundance at synapti...More

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