Cofilin-1 is involved in regulation of actin reorganization during influenza A virus assembly and budding.

•Influenza A virus infection enhances F-actin aggregation on host plasma membrane.•Influenza A virus infection increases cofilin-1 expression.•PGG inhibits virus-induced F-actin aggregation on plasma membrane.•PGG suppresses virus-induced cofilin-1 and its phosphorylation.•Knock-down of cofilin-1 reduces influenza A virus yields from host cells.