TCR signal quantity and quality in CD4(+) T cell differentiation.

Trends in Immunology（2014）

引用 118|浏览9

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摘要

•Single naïve CD4+ T cells produce different effector cell patterns.•TCR signal strength and quality are determinants of the effector cell pattern.•TCR-independent factors also influence the effector cell pattern.•A model of TCR-mediated Th1/Tfh/GC-Tfh differentiation is proposed.

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关键词

T cell differentiation,TCR signal strength,polyclonal

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