TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein

Sanchita Bhatnagar,Claude Gazin,Lynn Chamberlain,Jianhong Ou,Xiaochun Zhu,Jogender S. Tushir,Ching-Man Virbasius,Ling Lin,Lihua J. Zhu,Narendra Wajapeyee,Michael R. Green

NATURE（2014）

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摘要

The RING finger protein TRIM37 is encoded by a gene that is amplified in certain breast cancers, but its function is unknown; here, it is shown to mono-ubiquitinate histone H2A and repress gene expression, and to function as a breast cancer oncoprotein.

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关键词

Gene silencing

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