Metabolic characterization of meso-dihydroguaiaretic acid in liver microsomes and in mice.

Jang Su Jeon,Soo Jin Oh,Ji-Yoon Lee,Chang Seon Ryu,Young-Mi Kim,Byung Hoon Lee,Sang Kyum Kim

Food and Chemical Toxicology（2015）

引用 11|浏览7

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摘要

•MDGA is rapidly metabolized by CYP and UGT in HLMs and MLMs.•Extensive metabolism causes poor bioavailability of MDGA in mice.•MDGA exhibits selective CYP2E1 inhibitory activity in HLMs.•MDGA-induced CYP2E1 inhibition is competitive.

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关键词

meso-Dihydroguaiaretic acid,Metabolic stability,Pharmacokinetics,CYP inhibition,CYP2E1

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