The effects of sarcolipin over-expression in mouse skeletal muscle on metabolic activity.

John Butler,Neil Smyth,Robert Broadbridge,Claire E Council,Anthony G Lee,Claire J Stocker,David C Hislop,Jonathan R S Arch,Michael A Cawthorne,J Malcolm East

Archives of Biochemistry and Biophysics（2015）

引用 14|浏览6

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摘要

•Sarcolipin is insufficient to affect thermogenic activity of SERCA in mouse muscle.•The ratio of SLN to SERCA in total limb skeletal muscle is <0.0015mol/mol.•Knocking out this SLN in mice would have a small effect on SERCA function.•Overexpressing SLN in transgenic mice only resulted in 0.037mol SLN/mol SERCA.•SLN+/+ mice showed no evidence of an increase in thermogenesis.

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关键词

Sarcolipin,SERCA,Thermogenesis,Energy expenditure,Obesity,High fat diet

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