The molecular basis of rectal cancer.
CLINICS IN COLON AND RECTAL SURGERY(2015)
摘要
The majority of rectal carcinomas are sporadic in nature, and relevant testing for driver mutations to guide therapy is important. A thorough family history is necessary and helpful in elucidating a potential hereditary predilection for a patient's carcinoma. The adequate diagnosis of a heritable tendency toward colorectal carcinoma alters the management of a patient disease and permits the implementation of various surveillance algorithms as preventive measures.
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关键词
colorectal cancer,molecular testing,hereditary cancer,adenoma-carcinoma sequence
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