A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

Peng Wang,Juan-Carlos Alvarez-Perez,Dan P Felsenfeld,Hongtao Liu, Sharmila Sivendran,Aaron Bender,Anil Kumar,Roberto Sanchez,Donald K Scott,Adolfo Garcia-Ocaña,Andrew F Stewart

NATURE MEDICINE（2015）

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摘要

high-throughput chemical screen reveals that harmine and its analogs promote improved human pancreatic beta cell replication and function, thus identifying these molecules as a potential new class of antidiabetic agents.

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nature medicine, science

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