Consequences of Disrupted Notch Signaling in Bladder Cancer.

European Urology(2015)

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摘要
The Notch pathway, which controls stem cell maintenance and cell differentiation, is activated in certain cancers and therefore constitutes a therapeutic target. Especially in invasive urothelial carcinoma, the pathway is inactivated instead, and drugs inhibiting Notch signaling are likely contra-indicated.
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