Dysregulation of gene expression in human fetal endothelial cells from gestational diabetes in response to TGF-β1.

Emanuela Marcantoni,Melania Dovizio,Peadar O'Gaora,Luigia Di Francesco,Imen Bendaya,Simone Schiavone,Annalisa Trenti,Paloma Guillem-Llobat,Alessandra Zambon,Giovanni Battista Nardelli,Lucia Trevisi,Paola Patrignani,Orina Belton

Prostaglandins & Other Lipid Mediators（2015）

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摘要

•HUVEC exposed to a GDM milieu in vivo has reduced migratory capacity.•Dysregulated expression of TGF-β receptors is detected.•Human fetal endothelium of GDM women responds abnormally to TGF-β1.•Several genes involved in development, cell movement and migration were downregulated.•Altered transcriptome may affect cardiac morphogenesis and placental development.

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关键词

Gestational diabetes mellitus,HUVEC,TGF-β,Microarray

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