A rare truncating BRCA2 variant and genetic susceptibility to upper aerodigestive tract cancer

Journal of the National Cancer Institute, Volume 107, Issue 5, 2015.

Cited by: 26|Bibtex|Views2|DOI:https://doi.org/10.1093/jnci/djv037
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Other Links: pubmed.ncbi.nlm.nih.gov|academic.microsoft.com

Abstract:

Deleterious BRCA2 genetic variants markedly increase risk of developing breast cancer. A rare truncating BRCA2 genetic variant, rs11571833 (K3326X), has been associated with a 2.5-fold risk of lung squamous cell carcinoma but only a modest 26% increase in breast cancer risk. We analyzed the association between BRCA2 SNP rs11571833 and upp...More

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