Target-based biomarker selection - Mineralocorticoid receptor-related biomarkers and treatment outcome in major depression.

Matthias Büttner,Daniela Jezova,Brandon Greene,Carsten Konrad,Tilo Kircher,Harald Murck

Journal of Psychiatric Research（2015）

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摘要

Aldosterone and mineralocorticoid receptor (MR)-function have been related to depression. We examined central and peripheral parameters of MR-function in order to characterize their relationship to clinical treatment outcome after six weeks in patients with acute depression.

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关键词

Aldosterone,Cortisol,Mineralocorticoid receptor,Depressive disorder,Refractory depression,Therapy refractoriness,Salt appetite,Sodium,Magnesium,Systolic blood pressure,Heart rate variability,Slow wave sleep,Biomarker

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