Quantifying domain-ligand affinities and specificities by high-throughput holdup assay

Renaud Vincentelli,Katja Luck,Juline Poirson,Jolanta Polanowska, Julie Abdat,Marilyne Blémont, Jeremy Turchetto, François Iv, Kevin Ricquier,Marie-Laure Straub,Anne Forster,Patricia Cassonnet,Jean-Paul Borg,Yves Jacob,Murielle Masson,Yves Nominé,Jérôme Reboul,Nicolas Wolff,Sebastian Charbonnier,Gilles Travé

Nature methods（2015）

引用 65|浏览15

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摘要

This paper reports an approach to measure equilibrium binding affinities for interacting proteins in high throughput, allowing the rapid and quantitative profiling of the specificity of interaction motifs.

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关键词

Systems biology, Proteins, High-throughput screening

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