Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

Shiran Rabinovich,Lital Adler,Keren Yizhak,Alona Sarver,Alon Silberman,Shani Agron,Noa Stettner,Qin Sun,Alexander Brandis,Daniel Helbling, Stanley Korman,Shalev Itzkovitz,David Dimmock,Igor Ulitsky,Sandesh C. S. Nagamani,Eytan Ruppin,Ayelet Erez

NATURE（2015）

引用 273|浏览50

暂无评分

摘要

SS1, a urea cycle enzyme, promotes cancer cell proliferation by facilitating pyrimidine synthesis via CAD (carbamoyl-phosphate synthase 2, aspartate transcarbamylase, and dihydroorotase complex) activation.

查看译文

关键词

nature

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要