The topochemical synthesis of triazole-linked homobasic DNA.

Triazolyl-DNA ((TL)DNA), a DNA-analog wherein phosphodiester units are replaced by triazole motifs, is of great interest. We have synthesized (TL)DNA oligomers by adopting the Topochemical Azide-Alkyne Cycloaddition (TAAC) reaction. A nucleoside decorated with the azide and alkyne units crystallized with the proximal placement of the azide and alkyne units of the adjacent molecules and underwent the TAAC reaction to form (TL)DNA oligomers.