N-acetylcysteine amide, A Promising Antidote for Acetaminophen Toxicity.

•Glutathione depletion is an initiating event in the APAP-induced toxicity.•N-acetylcysteineamide offers better protection than N-acetylcysteine in APAP-induced hepatotoxicity.•N-acetylcysteineamide can be developed into a potential agent to treat the hepatotoxicity induced by APAP overdose.•Mitochondrial dysfunction is a key event in APAP-induced hepatotoxicity.