Tetrachlorobenzoquinone exhibits neurotoxicity by inducing inflammatory responses through ROS-mediated IKK/IκB/NF-κB signaling.

Juanli Fu,Qiong Shi,Xiufang Song,Xiaomin Xia,Chuanyang Su,Zixuan Liu,Erqun Song,Yang Song

Environmental Toxicology and Pharmacology（2016）

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摘要

•TCBQ exhibits neurotoxicity by inducing inflammatory responses.•TCBQ showed the highest capacity on inflammatory responses.•TCBQ induces inflammatory responses through IKK/IκB/NF-κB signaling pathway.•TCBQ-induced inflammatory responses are ROS-dependent.

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关键词

COX-2,ELISA,EMSA,ERK1/2,HCB,IκBα,IKK,IL-1β,IL-6,iNOS,JNK,MAPK,NAC,NF-κB,NO,PCP,PDTC,PGE2,POPs,ROS,TCBQ,TCHQ,TNF-α,VE

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