Absence of Sema4D improves oligodendrocyte recovery after cerebral ischemia/reperfusion injury in mice.

•The effect of Sema4D-deficiency on oligodendrocyte was studied in mice.•Direct ligation of the middle cerebral artery and reperfusion were employed.•The peri-infarct area showed a transient decrease of oligodendrocytes.•Sema4D KOs showed enhanced oligodendrocyte recovery compared to wild-type mice.•Sema4D-deficiency enhanced proliferation and survival of oligodendrocytes.